Semaglutide + Methylcobalamin
Compounded semaglutide, for a dose you can’t get commercially. Semaglutide and methylcobalamin, a form of vitamin B12, in one injection you use once a week, in a 1 mg or 4 mg per mL vial. Your provider prescribes it only when you need a dose or titration schedule the FDA-approved medicines don’t come in, and a licensed pharmacy prepares it from your prescription, up to 28 days at a time. Compounded medications are not FDA-approved; the FDA does not review them for safety, effectiveness or quality.
- Only for a dose or titration that isn’t commercially available
- Prepared for you by a licensed pharmacy, up to 28 days at a time
- Once a week, at home
- Not FDA-approved
Weekly injection · from $50/vial. Prices are preliminary.
How it works
- Answer the evaluation: your health and family history, your weight and goals, and every medicine and supplement you take.
- Get lab work if your provider asks for it.
- If your provider determines you need a dose that isn’t commercially available, a licensed pharmacy prepares a vial for up to 28 days at your dose and ships it in discreet packaging to protect your privacy, with instructions for your injections.
- Inject once a week, on the same day each week. Doses start low and go up slowly; your provider sets the pace.
- What’s in it
- Semaglutide 1 or 4 mg/mL with methylcobalamin (vitamin B12)
- Form
- A weekly injection under the skin, from a vial; your provider sets the dose
- Who it’s for
- Adults whose provider determines they need a dose or titration schedule the FDA-approved medicines don’t offer
- FDA status
- Not FDA-approved: the FDA does not review compounded medications for safety, effectiveness or quality
- Cost
- Vials from $50, shipping included; each is up to a 28-day supply. Visits: $65 to start, then $45 for each follow-up or dose change.
What’s inside.
- Semaglutide (1 or 4 mg/mL): A GLP-1 medication: it works like GLP-1, a hormone your body releases after meals that’s involved in appetite and blood sugar.
- Methylcobalamin (In every vial): A form of vitamin B12.
What to expect
- First weeks
- A low starting dose, to help your body adjust. Nausea and other stomach side effects are most common early on.
- The next few months
- Your provider adjusts your dose step by step, if you’re tolerating it, and checks in along the way.
- Ongoing
- Your provider reviews how it’s going and adjusts your plan. Everyone responds differently.
Important safety information
Before you start
Your provider reviews your health history, medicines and allergies before prescribing, and prescribes only if it’s right for you. Tell your care team about any side effect, and get emergency care for chest pain, trouble breathing, or swelling of the face, lips or throat.
Common side effects of GLP-1 medications
Nausea, diarrhea, vomiting, constipation, stomach pain, indigestion, headache and tiredness are the most common, usually early on and as the dose goes up. They often ease with time. Tell your provider if they don’t.
Important safety information for GLP-1 medications
GLP-1 medications for weight carry a boxed warning: in studies in rodents, they caused thyroid C-cell tumors. It isn’t known whether they cause these tumors, including medullary thyroid cancer, in people. Don’t take them if you or a family member has had medullary thyroid cancer, or if you have multiple endocrine neoplasia syndrome type 2 (MEN 2). Tell your provider right away about a lump or swelling in your neck, trouble swallowing, a hoarse voice or shortness of breath. They can also cause inflammation of the pancreas (pancreatitis), gallbladder problems, low blood sugar (especially with insulin or a sulfonylurea), kidney problems from dehydration, and serious allergic reactions. They aren’t used during pregnancy. Get emergency care for severe stomach pain that doesn’t go away, with or without vomiting.
FDA status
Not FDA-approved. The FDA does not review compounded medications for safety, effectiveness or quality. Your provider prescribes one only when you need a dose or titration schedule the FDA-approved medicines don’t come in.
About Semaglutide + Methylcobalamin
Why would my provider prescribe a compounded medication?
Only when you need a dose or titration schedule the FDA-approved medicines don’t come in, for example a smaller starting dose or smaller steps between doses. Otherwise, they’ll go over FDA-approved options with you.
Is it the same as an FDA-approved medication?
No. Compounded medications are not FDA-approved: the FDA does not review them for safety, effectiveness or quality.
What does it cost?
Semaglutide vials are $50 for 1 mg/mL, 1 mL vial, $60 for 1 mg/mL, 2 mL vial, $70 for 4 mg/mL, 1 mL vial, $75 for 4 mg/mL, 2 mL vial, shipping included; each is up to a 28-day supply. Visits: $65 to start, then $45 for each follow-up or dose change.